研究成果 (Publication)

論文 (Research article and review paper)

2019

Shinohara Y, Nishino Y, Yamanaka M, Ohmori K, Elbadawy M, Usui T, Sasaki K. Efficacy of Juzen-taiho-to against vincristine-induced toxicity in dogs. Vet Med Sci. in press.

Shinohara Y, Oyama A, Usui T, Sasaki K. Possible anti-oxidative effects of long-term administration of Juzen-taiho-to in dogs. J Vet Med Sci. 2019 Oct 4. doi: 10.1292/jvms.19-0380

Usui T1, Sasaki K1.[Study on colorectal cancer using air-liquid interface organoid culture method]. 2019;154(2):50-55. doi: 10.1254/fpj.154.50.

Elbadawy M, Usui T, Mori T, Tsunedomi R, Hazama S, Nabeta R, Uchide T, Fukushima R, Yoshida T, Shibutani M, Tanaka T, Masuda S, Okada R, Ichikawa R, Omatsu T, Mizutani T, Katayama Y, Noguchi S, Iwai S, Nakagawa T, Shinohara Y, Kaneda M, Yamawaki H, Sasaki K. Establishment of a novel experimental model for muscle-invasive bladder cancer by using dog bladder cancer organoid culture. Cancer Sci. 2019 Jun 29

Nabeta R, Nakagawa Y, Chiba S, Xiantao H, Usui T, Suzuki K, Furuya T, Fukushima R, Uchide T. Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression.  Front Vet Sci. 2019 Apr 18; 6:121

Elbadawy M, Usui T, Yamawaki H, Sasaki K. Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target
Against Colorectal Cancer. Int J Mol Sci. 2019, 20, 2340.

2018

Ogawa M, Osada H, Hasegawa A, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Kondo H, Ohmori K. Effect of interleukin-1β on occludin mRNA expression in the duodenal and colonic mucosa of dogs with inflammatory bowel disease. J Vet Intern Med. 2018 May;32(3):1019-1025

臼井達哉, 佐々木一昭. 2018. 肺がんオルガノイド・血管内皮細胞共培養システムを用いた細胞間相互作用メカニズムの解明. BIO Clinica. 34: 45-49.

Elbadawy M, Usui T, Yamawaki H, Sasaki K. Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. Int J Mol Sci. 2018 Oct 4;19(10). pii: E3031

Yabe R, Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T, Sato K. A stable association with PME-1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation. FEBS Open Bio. 2018 Aug 1;8(9):1486-1496.

Ogushi N, Sasaki K, Shimoda M. Effects of leucovorin (folinic acid) in the methotrexate-treated rat brain. J Vet Med Sci. 2018 May 18;80(5):760-765.

Elbadawy M, Usui T, Yamawaki H, Sasaki K. Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers (Basel). 2018 May 28;10(6). pii: E164

Usui T, Sakurai M, Umata K, Elbadawy M, Ohama T, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K, Kaneda M, Sasaki K. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture.  Int J Mol Sci. 2018 Apr 6;19(4). pii: E1098.

臼井達哉, 佐々木一昭. 2018. 三次元マウス肺がんモデルの確立とがん・血管内皮連関機構の解明. メディカル・サイエンス・ダイジェスト 44: 189-192.

Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, UsuiT, Ohama T, Sato K. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. Mol Cancer Res. Accepted.

Usui T, Sakurai M, Umata K, Yamawaki H, Ohama T, Sato. Preparation of human primary colon tissue-derived organoid using air liquid interface culture. Curr Protoc Toxicol. Accepted. 2018

Hasegawa A, Watanabe M, Osada H, Ogawa M, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Ohmori K. Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains.  Biochem Biophys Res Commun. 495(3):2184-2188, 2018

2017

Usui T, Sakurai M, Nishikawa S, Umata K, Nemoto Y, Haraguchi T, Itamoto K, Mizuno T, Noguchi S, Mori T, Iwai S, Nakagawa T, Yamawaki H, Ohama T, Sato K. Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells. Cancer Sci. 2017 Dec;108(12):2383-2392.

Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T, Sato K. The role of SET/I2PP2A in canine mammary tumors. Sci Rep. 7: 4279. 2017.

Kawasaki H, Saotome T, Usui T, Ohama T, Sato K. Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor. Oncol Rep. 37:3128-3136. 2017.

Usui T, Sakurai M, Kawasaki H, Ohama T, Yamawaki H, Sato K. Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis. Physiol Rep. 5:e13318.2017.

Nagasue R, Murata I, Sasaki K, Sakai R, Miyajima H, Shimoda M. Effectiveness of the liver micronucleus assay using juvenile mice. J Vet Med Sci.. 79(7):1310-1317. 2017

Osada H, Ogawa M, Hasegawa A, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Kondo H, Ohmori K. Expression of epithelial cell-derived cytokine genes in the duodenal and colonic mucosae of dogs with chronic enteropathy. J Vet Med Sci.. 79(2):393-397. 2017

Ogushi N, Sasaki K, Shimoda M. CAN a P-gp modulator assist in the control of methotrexate concentrations in the rat brain? -inhibitory effects of rhodamine 123, a specific substrate for P-gp, on methotrexate excretion from the rat brain and its optimal route of administration. J Vet Med Sci. 79(2):320-327. 2017

2016

Usui T, Sakurai M, Enjoji S, Kawasaki H, Umata K, Ohama T, Fujiwara N, Yabe R, Tsuji S, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment. Stem cells int. 7053872. 2016.

Tsuji S, Yabe R, Usui T, Mizuno T, Ohama T, Sato K. Anti-tumor effects of perphenazine on canine lymphoma. J Vet Med Sci. 78:1293-1298. 2016.

Kake S and *Usui T, Ohama T, Sato K. Death-associated protein kinase 3 controls tumor progression of A549 cells through ERK MAPK/c-Myc signaling. Oncol rep. 37:1100-1106. 2016.

Fujiwara N, Usui T, Ohama T, Sato K. Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). J Biol Chem. 291:10858-10866. 2016.

Watanabe M, Osada H, Shimizu S, Goto S, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Ohmori K. Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. Am J Vet Res. 77(9):969-75. 2016

Goto S, Shimizu S, Watanabe M, Osada H, Sasaki K, Shimoda M, Nagai M, Shirai J, Itoh H, Ohmori K. Influence of glucocorticoids on a time-of-day-dependent variation in intradermal reactivity to histamine in dogs. Vet J. 214:86-90. 2016

Sawaguchi A, Sasaki K, Miyanaga K, Nakayama M, Nagasue M, Shimoda M. Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle. J Vet Med Sci. 78(9):1481-1485. 2016

Elbadawy M, Ishihara Y, Aboubakr M, Sasaki K, Shimoda M. Oral absorption profiles of sulfonamides in Shiba goats: a comparison among sulfadimidine, sulfadiazine and sulfanilamide. J Vet Med Sci. 78(6):1025-9. 2016

2015

Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T, Sato K. Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation. PLoS One. 10:e0145226. 2015.

Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K. The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. J Vet Med Sci. 77:1451-1456. 2015.

Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, Yamawaki H. Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells. Acta Physiologica (Oxf) 213:472-480. 2015.

Sasaki K, Shimoda M. Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review. J Adv Res. 6(3):383-92. 2015

Elbadawy M, Sasaki K, Miyazaki Y, Aboubakr M, Khalil WF, Shimoda M. Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats. J Vet Med Sci. ;77(10):1331-4. 2015

E Ogushi N, Sasaki K, Shimoda M. Effect of cyclosporin on distribution of methotrexate into the brain of rats. J Vet Med Sci. ; 77(9):1171-3. 2015

Elbadawy M, Sakiyama T, Abohatab R, Sasaki K, Shimoda M. Oral pharmacokinetics of the acidic drugs, diclofenac and sulfamonomethoxine in male Shiba goats. J Vet Med Sci. ; 77(1):21-6. 2015

2014

Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T, Sato K. Characterization of SET/I2PP2A isoforms in dogs. J Vet Med Sci. 76:1235-1240. 2014.

Usui T, Sakatsume T, Nijima R, Otani K, Kazama K, Morita T, Kameshima S, Okada M, Yamawaki H. Death-associated protein kinase3 mediates vascular structural remodeling via stimulating smooth muscle cell proliferation and migration. Clin Sci (Lond). 127:539-548. 2014.

Usui T, Naruo A, Okada M, Hayabe Y, Yamawaki H. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells. Acta Physiologica (Oxf). 211:385-394. 2014.

Usui T, Morita T, Okada M, Yamawaki H. Histone deacetylase (HDAC) 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells. Hypertension. 63:397-403. 2014.

Usui T, Okada M, Yamawaki H. Zipper interacting protein kinase (ZIPK): function and signaling. Apoptosis. 19:387-391. 2014.

 

2013

臼井達哉, 岡田宗善, 原幸男, 山脇英之. 2013. 高血圧症の病態を制御する新たなカルモジュリン関連蛋白質の血管系における機能. 日本薬理学雑誌. 141: 85-89.