研究成果 (Publication)

論文 (Research article and review paper)

2024

Ting-Wei Yu 1Haru Yamamoto 1Shohei Morita 2Ryuji Fukushima 2Mohamed Elbadawy 1 3 4Tatsuya Usui 1Kazuaki Sasaki Comparative pharmacokinetics of tyrosine kinase inhibitor, lapatinib, in dogs and cats following single oral administration. J Vet Med Sci2024 Jan 29. doi: 10.1292/jvms.23-0448

2023

Hussein M. El-Husseiny , Eman A. Mady  , Tatsuya Usui , Yusuke Ishihara , Toshinori Yoshida,Mio Kobayashi , Kenta Sasaki, Danfu Ma , Akira Yairo , Ahmed S. Mandour , Hanan Hendawy, Ahmed S. Doghish, Osama A. Mohammed, Ken Takahashi  and Ryou Tanaka, Adipose Stem Cell-Seeded Decellularized Porcine Pericardium: A Promising Functional Biomaterial to Synergistically Restore the Cardiac Functions Post-Myocardial Infarction. Vet. Sci. 2023, 10, 660.

Rina Nabeta1 Ami Kanaya1 Mohamed Elbadawy1, 2 Tatsuya Usui1 Tetsuya Furuya1 Kazuhiko Suzuki1 Tsuyoshi UchideChemosensitivity of Three Patient-derived Primary Cultures of Canine Pericardial Mesothelioma by Single-agent and Combination Treatment. Front. Vet. Sci. Volume 10 – 2023 | doi: 10.3389/fvets.2023.1267359

Ameen A. Salahudeen,, Jose A. Seoane, Kanako Yuki, Amanda T. Mah, Amber R. Smith,
Kevin Kolahi, Sean M. De la O, Daniel J. Hart, Jie Ding, Zhicheng Ma, Sammy A. Barkal, Navika D. Shukla,
Chuck H. Zhang, Michael A. Cantrell, Arpit Batish, Tatsuya Usui, David Root, William Hahn, Christina Curtis,and Calvin J. Kuo. Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis. Cell Reports,42(11):113355. doi: 10.1016/j.celrep.2023.113355.

 Mohamed Elbadawy, Kiwamu Tanabe, Yusuke Ishihara, Haru Yamamoto, Maria Mochizuki, Amira Abugomaa, Hideyuki Yamawaki, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki. Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using nonalcoholic steatohepatitis (NASH) liver organoids Frontiers in Pharmacology14:1243258. 2023.

Sumire Shimada 1Mohamed Aboubakr 1 2Mohamed Elbadawy 1 2Tatsuya Usui 1Kazuaki Sasaki 1Minoru Shimoda Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits.  J Vet Med Sci2023 Aug 25. doi: 10.1292/jvms.23-0246

ny , Eman A. Mady, Masahiro Kaneda, Kazumi Shimada,Yasumoto Nakazawa, Tatsuya Usui, Mohamed Elbadawy, Yusuke Ishihara, Moeko Hirose, Yohei Kamei, Ahmed S. Doghish, Hesham A. El-Mahdy, Walaa A. El-Dakroury and Ryou Tanaka, Comparison of Bovine- and Porcine-Derived Decellularized Biomaterials: Promising Platforms for Tissue Engineering Applications. Pharmaceutics. 15, 1906. 2023.

Yomogi Shiota (Sato), Mohamed Elbadawy, Kazuhiko Suzuki, Ryouichi Tsunedomi, Hiroaki Nagano, Yusuke Ishihara, Haru Yamamoto, Daigo Azakami, Tsuyoshi Uchide, Ryuji Fukushima, Ryo Tanaka, Tomohiko Yoshida, Takuya Mori, Amira Abugomaa, Masahiro Kaneda, Hideyuki Yamawaki, Yuta Shinohara, Mohamed Aboubakr, Mohamed E. El-Asrag, Tatsuya Usui, Kazuaki Sasaki. Derivation of a new model of lung adenocarcinoma using canine lung cancer organoids for translational research in pulmonary medicine. Biomedicine & Pharmacotherapy, 165: 115079. 2023 

Tsuyoshi TajimaMasumi SaigaHaru YamamotoMohamed Elbadawy Amira AbugomaaRyotaro MiuraTatsuya Usui Kazuaki Sasaki Minoru Shimoda . Oral Pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows, J Vet Med Sci. 85:715-720. 2023.

Abugomaa A, Elbadawy M, Ishihara Y, Yamamoto H, Kaneda, M, Yamawaki, H, Shinohara Y, *Usui T, Sasaki, K. Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids, Frontiers in Pharmacology14:1159516. 2023.

Sato Y, Elbadawy M, Suzuki K, Tsunedomi R, Nagano H, Ishihara Y, Yamamoto H, Azakami D, Kaneda M, Ishihara, Y, Sato, Y, Yamawaki, H, Kaneda, M, Usui T, Sasaki, K. Establishment of an experimental model of canine malignant mesothelioma organoid culture using a three-dimensional culture method. Biomedicine & Pharmacotherapy, 162: 114651. 2023 

2022

Abugomaa A, Elbadawy M, Yamamoto H, Ayame, H, Ishihara, Y, Sato, Y, Yamawaki, H, Kaneda, M, Usui, T, Sasaki, K. Establishment of a direct 2.5D organoid culture model using companion animal cancer tissues. Biomedicine & Pharmacotherapy. 154:113597.

Shinohara Y, Elbadawy M, Yamanaka M, Yamamoto H, Abugomaa A, Usui T, Sasaki K. Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs. J Vet Med Sci. 84: 841-846 

Elbadawy M, Fujisaka K, Yamamoto H, Tsunedomi R, Nagano H, Ayame H, Ishihara Y, Mori T, Azakami D, Uchide T, Fukushima R, Abugomaa A, Kaneda M, Yamawaki H, Shinohara Y, Omatsu T, Mizutani T, Usui T, Sasaki K. Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture method. Biomed Pharmacother. in press.

Endo T. Nakagomi Y. Kawaguchi E. Hayakawa E. Nam H. Takemae H. Shinohara Y. Yang D. Usui T. Mizutani T. Nakao Y. Furuya T. Anti-malarial activity in a Chinese herbal supplement containing Inonotus obliquus and Panax notoginseng. Parasitology International. 2022. 87:102532.

佐藤よもぎ、Mohamed Elbadawy、山本晴、森正弘、森崇、中川貴之、前田真吾、野口俊助、岩井聡美、呰上大吾、打出毅、福島隆治、篠原佑太、臼井達哉、佐々木一昭. 尿サンプル由来イヌ移行上皮癌オルガノイド培養法を用いた抗がん剤感受性検査の開発. 日本獣医腎泌尿器学雑誌 14 巻 1号 p4.

 Yoshida T, Kobayashi M, Umemoto S, Oshima K, Hara E, Katoh Y, Takahashi N, Harada T, Usui T, Elbadawy M, Shibutani M. “The Potential of Organoids in Toxicologic Pathology”How should toxicologic pathologists participate in the growing field of in vitro hepatotoxicity assessment? Journal of Toxixologic Pathology. 35: 225-235. 2022

2021

NASHモデルマウス由来肝臓オルガノイドの開発と創薬への応用, 山本晴, 臼井 達哉, 佐々木 一昭 日本薬理学雑誌 2021 年156 巻 5 号 p. 275-281.

健常犬におけるテルミサルタンの血中動態解析と薬用量の決定
福島 隆治, 河口 貴恵, 桜井 柚里穂, 橋本 梨那, 安川 洋子, 吉村 有正, 山田 修作, 平尾 大樹, 大森 貴裕, 森田 祥平, 臼井 達哉, 佐々木 一昭
動物の循環器 2021 年 54 巻 2 号 p. 61-68

Yamamoto H, Elbadawy M, Fujisaka K, Sato Y, Ohmori T, Shinohara Y, Hatano Y, Kobayashi D, Gomyo A, Sudo Y, Azakami D, Uchide T, Fukushima R, Morita S, Abugomaa A, Yamawaki H, Kaneda M, Usui T, Sasaki K. Evaluation of the Safety and Feasibility of Apheresis in Dogs: For Application in Metastatic Cancer Research. Animals (Basel)2021 Sep 23;11(10):2770. doi: 10.3390/ani11102770.

Elbadawy M,Kato Y, Saito N, Hayashi KAbugomaa A, Kobayashi MYoshida T, Shibutani M, Kaneda M,  Yamawaki H Mizutani Lim C, Saijo MSasaki K, Usui TOmatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 22:10763. 2021. 

Elbadawy M, Hayashi K, Ayame H, Ishihara Y, Abugomaa A, Shibutani M, Hayashi S, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Shinohara Y, Kaneda M,  Yamawaki H ,  Usui TSasaki K. Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. Biomed Pharmacother. 142:112043. 2021. 

Elbadawy M, Sato Y, Mori T, Goto Y, Hayashi K, Yamanaka M, Azakami D, Uchide T, Fukushima R, Yoshida T, Shibutani M, Kobayashi M, Shinohara Y, Abugomaa A, Kaneda M, Yamawaki H, Usui T, Sasaki.K. Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism. Cancer Biol Ther. 22:357-371. 2021. 

2020

Ameen A. Salahudeen, Shannon S. Choi, Arjun Rustagi, Junjie Zhu, Vincent van Unen, Sean M. de la O, Ryan A. Flynn , Mar Margalef-Català , António J. M. Santos , Jihang Ju, Arpit Batish, Tatsuya Usui, Grace X. Y. Zheng, Caitlin E. Edwards, Lisa E. Wagar, Vincent Luca, Benedict Anchang, Monica Nagendran, Khanh Nguyen, Daniel J. Hart , Jessica M. Terry, Phillip Belgrader, Solongo B. Ziraldo, Tarjei S. Mikkelsen, Pehr B. Harbury, Jeffrey S. Glenn, K. Christopher Garcia, Mark M. Davis, Ralph S. Baric, Chiara Sabatti, Manuel R. Amieva, Catherine A. Blish, Tushar J. Desai, Calvin J. Kuo. Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature, in press. 2020.

Fujiwara N, Shibutani S, Sakai Y, Watanabe T, Kitabayashi I, Oshima H, Oshima M, Hoshida H, Akada R, Usui T, Ohama T, Sato K. Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6. Cancer Sci, in press. 2020.

Amira Abugomaa 1 2Mohamed Elbadawy 1 3Megumi Yamanaka 1Yuta Goto 1Kimika Hayashi 1Takashi Mori 4 5Tsuyoshi Uchide 6Daigo Azakami 7Ryuji Fukushima 8Toshinori Yoshida 9Makoto Shibutani 9Risako Yamashita 9Mio Kobayashi 9Hideyuki Yamawaki 10Yuta Shinohara 1 11Masahiro Kaneda 12Tatsuya Usui 13Kazuaki Sasaki . Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture.  Sci Rep. 2020 Jun 10;10(1):9393. doi: 10.1038/s41598-020-66229-w.

 Elbadawy M, Abugomaa A, Yamawaki H, Usui T, Sasaki K. Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research. Cancers (Basel). 2020 Mar 25;12(4).

Abdou RH, Elbadawy M, Khalil WF, Usui T, Sasaki K, Shimoda M. Effects of several organophosphates on hepatic cytochrome P450 activities in rats. J Vet Med Sci. 2020 Mar 25. doi: 10.1292/jvms.19-0452

MohamedElbadawyabMegumiYamanakaaYutaGotoaKimikaHayashiaRyouichiTsunedomicShoichiHazamacdHiroakiNaganocToshinoriYoshidaeMakotoShibutanieRyoIchikawaeJuntaNakaharaeTsutomuOmatsufTetsuyaMizutanifYukieKatayamafYutaShinoharaagAmiraAbugomaaaMasahiroKanedahHideyukiYamawakiiKazuakiSasaki, Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model, Biomaterials, 2020, Volume 237, April 2020, 119823

Amira Abgomaa, Elbadawy M, Usui T, Yamawaki H, Sasaki K. Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer. Cells. 2020, 9(1), 235; https://doi.org/10.3390/cells9010235

Passive immunization against inhibin increases testicular blood flow in male goats. Samir H, El Sayed MAI, Nagaoka K, Sasaki K, Abo El-Maaty AM, Karen A, Abou-Ahmed MM, Watanabe G. Theriogenology. 2020 Feb 17;147:85-91

Administration of melatonin improves testicular blood flow, circulating hormones, and semen quality in Shiba goats.  Samir H, Nyametease P, Elbadawy M, Nagaoka K, Sasaki K, Watanabe G. Theriogenology. 2020 Apr 1;146:111-119

2019

Shinohara Y, Nishino Y, Yamanaka M, Ohmori K, Elbadawy M, Usui T, Sasaki K. Efficacy of Juzen-taiho-to against vincristine-induced toxicity in dogs. J Vet Med Sci. 2019 Dec 26;81(12):1810-1816. doi: 10.1292/jvms.19-0401.

Shinohara Y, Oyama A, Usui T, Sasaki K. Possible anti-oxidative effects of long-term administration of Juzen-taiho-to in dogs. J Vet Med Sci. 2019 Oct 4. doi: 10.1292/jvms.19-0380

Usui T1, Sasaki K1.[Study on colorectal cancer using air-liquid interface organoid culture method]. 2019;154(2):50-55. doi: 10.1254/fpj.154.50.

Elbadawy M, Usui T, Mori T, Tsunedomi R, Hazama S, Nabeta R, Uchide T, Fukushima R, Yoshida T, Shibutani M, Tanaka T, Masuda S, Okada R, Ichikawa R, Omatsu T, Mizutani T, Katayama Y, Noguchi S, Iwai S, Nakagawa T, Shinohara Y, Kaneda M, Yamawaki H, Sasaki K. Establishment of a novel experimental model for muscle-invasive bladder cancer by using dog bladder cancer organoid culture. Cancer Sci. 2019 Sep;110(9):2806-2821. doi: 10.1111/cas.14118

Nabeta R, Nakagawa Y, Chiba S, Xiantao H, Usui T, Suzuki K, Furuya T, Fukushima R, Uchide T. Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression.  Front Vet Sci. 2019 Apr 18; 6:121

Elbadawy M, Usui T, Yamawaki H, Sasaki K. Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target
Against Colorectal Cancer. Int J Mol Sci. 2019, 20, 2340.

Effects of a selective casein kinase 1δ and ε inhibitor on FcεRI expression and IgE-mediated immediate-type cutaneous reactions in dogs. Ohno H, Takahashi K, Yanuma N, Ogawa M, Hasegawa A, Sugita K, Kawano K, Sasaki K, Shirai J, Nagaoka K, Ohmori K. J Vet Med Sci. 2019 Dec 5;81(11):1680-1684.

Samir H, Kandiel MMM, El-Maaty AMA, Sediqyar M, Sasaki K, Watanabe G. Ovarian follicular changes and hemodynamics in Egyptian buffaloes under CIDR-PGF2α and Ovsynch-CIDR estrus synchronization treatments.  J Reprod Dev. 2019 Oct 23;65(5):451-457

2018

Ogawa M, Osada H, Hasegawa A, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Kondo H, Ohmori K. Effect of interleukin-1β on occludin mRNA expression in the duodenal and colonic mucosa of dogs with inflammatory bowel disease. J Vet Intern Med. 2018 May;32(3):1019-1025

臼井達哉, 佐々木一昭. 2018. 肺がんオルガノイド・血管内皮細胞共培養システムを用いた細胞間相互作用メカニズムの解明. BIO Clinica. 34: 45-49.

Elbadawy M, Usui T, Yamawaki H, Sasaki K. Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. Int J Mol Sci. 2018 Oct 4;19(10). pii: E3031

Yabe R, Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T, Sato K. A stable association with PME-1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation. FEBS Open Bio. 2018 Aug 1;8(9):1486-1496.

Ogushi N, Sasaki K, Shimoda M. Effects of leucovorin (folinic acid) in the methotrexate-treated rat brain. J Vet Med Sci. 2018 May 18;80(5):760-765.

Elbadawy M, Usui T, Yamawaki H, Sasaki K. Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers (Basel). 2018 May 28;10(6). pii: E164

Usui T, Sakurai M, Umata K, Elbadawy M, Ohama T, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K, Kaneda M, Sasaki K. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture.  Int J Mol Sci. 2018 Apr 6;19(4). pii: E1098.

臼井達哉, 佐々木一昭. 2018. 三次元マウス肺がんモデルの確立とがん・血管内皮連関機構の解明. メディカル・サイエンス・ダイジェスト 44: 189-192.

Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, UsuiT, Ohama T, Sato K. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. Mol Cancer Res. Accepted.

Usui T, Sakurai M, Umata K, Yamawaki H, Ohama T, Sato. Preparation of human primary colon tissue-derived organoid using air liquid interface culture. Curr Protoc Toxicol. Accepted. 2018

Hasegawa A, Watanabe M, Osada H, Ogawa M, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Ohmori K. Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains.  Biochem Biophys Res Commun. 495(3):2184-2188, 2018

2017

Usui T, Sakurai M, Nishikawa S, Umata K, Nemoto Y, Haraguchi T, Itamoto K, Mizuno T, Noguchi S, Mori T, Iwai S, Nakagawa T, Yamawaki H, Ohama T, Sato K. Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells. Cancer Sci. 2017 Dec;108(12):2383-2392.

Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T, Sato K. The role of SET/I2PP2A in canine mammary tumors. Sci Rep. 7: 4279. 2017.

Kawasaki H, Saotome T, Usui T, Ohama T, Sato K. Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor. Oncol Rep. 37:3128-3136. 2017.

Usui T, Sakurai M, Kawasaki H, Ohama T, Yamawaki H, Sato K. Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis. Physiol Rep. 5:e13318.2017.

Nagasue R, Murata I, Sasaki K, Sakai R, Miyajima H, Shimoda M. Effectiveness of the liver micronucleus assay using juvenile mice. J Vet Med Sci.. 79(7):1310-1317. 2017

Osada H, Ogawa M, Hasegawa A, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Kondo H, Ohmori K. Expression of epithelial cell-derived cytokine genes in the duodenal and colonic mucosae of dogs with chronic enteropathy. J Vet Med Sci.. 79(2):393-397. 2017

Ogushi N, Sasaki K, Shimoda M. CAN a P-gp modulator assist in the control of methotrexate concentrations in the rat brain? -inhibitory effects of rhodamine 123, a specific substrate for P-gp, on methotrexate excretion from the rat brain and its optimal route of administration. J Vet Med Sci. 79(2):320-327. 2017

2016

Usui T, Sakurai M, Enjoji S, Kawasaki H, Umata K, Ohama T, Fujiwara N, Yabe R, Tsuji S, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment. Stem cells int. 7053872. 2016.

Tsuji S, Yabe R, Usui T, Mizuno T, Ohama T, Sato K. Anti-tumor effects of perphenazine on canine lymphoma. J Vet Med Sci. 78:1293-1298. 2016.

Kake S and *Usui T, Ohama T, Sato K. Death-associated protein kinase 3 controls tumor progression of A549 cells through ERK MAPK/c-Myc signaling. Oncol rep. 37:1100-1106. 2016.

Fujiwara N, Usui T, Ohama T, Sato K. Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). J Biol Chem. 291:10858-10866. 2016.

Watanabe M, Osada H, Shimizu S, Goto S, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Ohmori K. Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. Am J Vet Res. 77(9):969-75. 2016

Goto S, Shimizu S, Watanabe M, Osada H, Sasaki K, Shimoda M, Nagai M, Shirai J, Itoh H, Ohmori K. Influence of glucocorticoids on a time-of-day-dependent variation in intradermal reactivity to histamine in dogs. Vet J. 214:86-90. 2016

Sawaguchi A, Sasaki K, Miyanaga K, Nakayama M, Nagasue M, Shimoda M. Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle. J Vet Med Sci. 78(9):1481-1485. 2016

Elbadawy M, Ishihara Y, Aboubakr M, Sasaki K, Shimoda M. Oral absorption profiles of sulfonamides in Shiba goats: a comparison among sulfadimidine, sulfadiazine and sulfanilamide. J Vet Med Sci. 78(6):1025-9. 2016

2015

Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T, Sato K. Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation. PLoS One. 10:e0145226. 2015.

Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K. The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. J Vet Med Sci. 77:1451-1456. 2015.

Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, Yamawaki H. Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells. Acta Physiologica (Oxf) 213:472-480. 2015.

Sasaki K, Shimoda M. Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review. J Adv Res. 6(3):383-92. 2015

Elbadawy M, Sasaki K, Miyazaki Y, Aboubakr M, Khalil WF, Shimoda M. Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats. J Vet Med Sci. ;77(10):1331-4. 2015

E Ogushi N, Sasaki K, Shimoda M. Effect of cyclosporin on distribution of methotrexate into the brain of rats. J Vet Med Sci. ; 77(9):1171-3. 2015

Elbadawy M, Sakiyama T, Abohatab R, Sasaki K, Shimoda M. Oral pharmacokinetics of the acidic drugs, diclofenac and sulfamonomethoxine in male Shiba goats. J Vet Med Sci. ; 77(1):21-6. 2015

2014

Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T, Sato K. Characterization of SET/I2PP2A isoforms in dogs. J Vet Med Sci. 76:1235-1240. 2014.

Usui T, Sakatsume T, Nijima R, Otani K, Kazama K, Morita T, Kameshima S, Okada M, Yamawaki H. Death-associated protein kinase3 mediates vascular structural remodeling via stimulating smooth muscle cell proliferation and migration. Clin Sci (Lond). 127:539-548. 2014.

Usui T, Naruo A, Okada M, Hayabe Y, Yamawaki H. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells. Acta Physiologica (Oxf). 211:385-394. 2014.

Usui T, Morita T, Okada M, Yamawaki H. Histone deacetylase (HDAC) 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells. Hypertension. 63:397-403. 2014.

Usui T, Okada M, Yamawaki H. Zipper interacting protein kinase (ZIPK): function and signaling. Apoptosis. 19:387-391. 2014.

 

2013

臼井達哉, 岡田宗善, 原幸男, 山脇英之. 2013. 高血圧症の病態を制御する新たなカルモジュリン関連蛋白質の血管系における機能. 日本薬理学雑誌. 141: 85-89.