論文 (Research article and review paper)
2024
Salinomycin induces apoptosis and potentiates the antitumor effect of doxorubicin against feline mammary tumor 2.5D organoids. J Vet Med Sci. 2024 Oct 22. doi: 10.1292/jvms.24-0344.
Comparative pharmacokinetics of tyrosine kinase inhibitor, lapatinib, in dogs and cats following single oral administration. J Vet Med Sci. 2024 Jan 29. doi: 10.1292/jvms.23-0448
2023
Rina Nabeta1 Ami Kanaya1 Mohamed Elbadawy1, 2 Tatsuya Usui1 Tetsuya Furuya1 Kazuhiko Suzuki1 Tsuyoshi Uchide1 Chemosensitivity of Three Patient-derived Primary Cultures of Canine Pericardial Mesothelioma by Single-agent and Combination Treatment. Front. Vet. Sci. Volume 10 – 2023 | doi: 10.3389/fvets.2023.1267359
Ameen A. Salahudeen,, Jose A. Seoane, Kanako Yuki, Amanda T. Mah, Amber R. Smith,
Kevin Kolahi, Sean M. De la O, Daniel J. Hart, Jie Ding, Zhicheng Ma, Sammy A. Barkal, Navika D. Shukla,
Chuck H. Zhang, Michael A. Cantrell, Arpit Batish, Tatsuya Usui, David Root, William Hahn, Christina Curtis,and Calvin J. Kuo. Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis. Cell Reports,42(11):113355. doi: 10.1016/j.celrep.2023.113355.
Mohamed Elbadawy, Kiwamu Tanabe, Yusuke Ishihara, Haru Yamamoto, Maria Mochizuki, Amira Abugomaa, Hideyuki Yamawaki, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki. Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using nonalcoholic steatohepatitis (NASH) liver organoids Frontiers in Pharmacology, 14:1243258. 2023.
Sumire Shimada1, Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits. J Vet Med Sci. 2023 Aug 25. doi: 10.1292/jvms.23-0246
ny , Eman A. Mady, Masahiro Kaneda, Kazumi Shimada,Yasumoto Nakazawa, Tatsuya Usui, Mohamed Elbadawy, Yusuke Ishihara, Moeko Hirose, Yohei Kamei, Ahmed S. Doghish, Hesham A. El-Mahdy, Walaa A. El-Dakroury and Ryou Tanaka, Comparison of Bovine- and Porcine-Derived Decellularized Biomaterials: Promising Platforms for Tissue Engineering Applications. Pharmaceutics. 15, 1906. 2023.
Oral Pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows, J Vet Med Sci. 85:715-720. 2023.
2022
2021
NASHモデルマウス由来肝臓オルガノイドの開発と創薬への応用, 山本晴, 臼井 達哉, 佐々木 一昭 日本薬理学雑誌 2021 年156 巻 5 号 p. 275-281.
Elbadawy M,Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H , Mizutani, Lim C, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 22：10763. 2021.
Elbadawy M, Hayashi K, Ayame H, Ishihara Y, Abugomaa A, Shibutani M, Hayashi S, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Shinohara Y, Kaneda M, Yamawaki H , Usui T, Sasaki K. Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. Biomed Pharmacother. 142：112043. 2021.
2020
Ameen A. Salahudeen, Shannon S. Choi, Arjun Rustagi, Junjie Zhu, Vincent van Unen, Sean M. de la O, Ryan A. Flynn , Mar Margalef-Català , António J. M. Santos , Jihang Ju, Arpit Batish, Tatsuya Usui, Grace X. Y. Zheng, Caitlin E. Edwards, Lisa E. Wagar, Vincent Luca, Benedict Anchang, Monica Nagendran, Khanh Nguyen, Daniel J. Hart , Jessica M. Terry, Phillip Belgrader, Solongo B. Ziraldo, Tarjei S. Mikkelsen, Pehr B. Harbury, Jeffrey S. Glenn, K. Christopher Garcia, Mark M. Davis, Ralph S. Baric, Chiara Sabatti, Manuel R. Amieva, Catherine A. Blish, Tushar J. Desai, Calvin J. Kuo. Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature, in press. 2020.
Fujiwara N, Shibutani S, Sakai Y, Watanabe T, Kitabayashi I, Oshima H, Oshima M, Hoshida H, Akada R, Usui T, Ohama T, Sato K. Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6. Cancer Sci, in press. 2020.
Elbadawy M, Abugomaa A, Yamawaki H, Usui T, Sasaki K. Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research. Cancers (Basel). 2020 Mar 25;12(4).
Abdou RH, Elbadawy M, Khalil WF, Usui T, Sasaki K, Shimoda M. Effects of several organophosphates on hepatic cytochrome P450 activities in rats. J Vet Med Sci. 2020 Mar 25. doi: 10.1292/jvms.19-0452
Sayed N, Abdalla O, Kilany O, Dessouki A, Yoshida T, Sasaki K, Shimoda M. Effect of dapagliflozin alone and in combination with insulin in a rat model of type 1 diabetes. J Vet Med Sci. 2020 Mar 11. doi: 10.1292/jvms.19-0450
MohamedElbadawyabMegumiYamanakaaYutaGotoaKimikaHayashiaRyouichiTsunedomicShoichiHazamacdHiroakiNaganocToshinoriYoshidaeMakotoShibutanieRyoIchikawaeJuntaNakaharaeTsutomuOmatsufTetsuyaMizutanifYukieKatayamafYutaShinoharaagAmiraAbugomaaaMasahiroKanedahHideyukiYamawakii…KazuakiSasaki, Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model, Biomaterials, 2020, Volume 237, April 2020, 119823
Amira Abgomaa, Elbadawy M, Usui T, Yamawaki H, Sasaki K. Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer. Cells. 2020, 9(1), 235; https://doi.org/10.3390/cells9010235
Passive immunization against inhibin increases testicular blood flow in male goats. Samir H, El Sayed MAI, Nagaoka K, Sasaki K, Abo El-Maaty AM, Karen A, Abou-Ahmed MM, Watanabe G. Theriogenology. 2020 Feb 17;147:85-91
Administration of melatonin improves testicular blood flow, circulating hormones, and semen quality in Shiba goats. Samir H, Nyametease P, Elbadawy M, Nagaoka K, Sasaki K, Watanabe G. Theriogenology. 2020 Apr 1;146:111-119
2019
Shinohara Y, Nishino Y, Yamanaka M, Ohmori K, Elbadawy M, Usui T, Sasaki K. Efficacy of Juzen-taiho-to against vincristine-induced toxicity in dogs. J Vet Med Sci. 2019 Dec 26;81(12):1810-1816. doi: 10.1292/jvms.19-0401.
Shinohara Y, Oyama A, Usui T, Sasaki K. Possible anti-oxidative effects of long-term administration of Juzen-taiho-to in dogs. J Vet Med Sci. 2019 Oct 4. doi: 10.1292/jvms.19-0380
Usui T1, Sasaki K1.[Study on colorectal cancer using air-liquid interface organoid culture method]. Nihon Yakurigaku Zasshi. 2019;154(2):50-55. doi: 10.1254/fpj.154.50.
Elbadawy M, Usui T, Mori T, Tsunedomi R, Hazama S, Nabeta R, Uchide T, Fukushima R, Yoshida T, Shibutani M, Tanaka T, Masuda S, Okada R, Ichikawa R, Omatsu T, Mizutani T, Katayama Y, Noguchi S, Iwai S, Nakagawa T, Shinohara Y, Kaneda M, Yamawaki H, Sasaki K. Establishment of a novel experimental model for muscle-invasive bladder cancer by using dog bladder cancer organoid culture. Cancer Sci. 2019 Sep;110(9):2806-2821. doi: 10.1111/cas.14118
Nabeta R, Nakagawa Y, Chiba S, Xiantao H, Usui T, Suzuki K, Furuya T, Fukushima R, Uchide T. Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression. Front Vet Sci. 2019 Apr 18; 6:121
Elbadawy M, Usui T, Yamawaki H, Sasaki K. Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target
Against Colorectal Cancer. Int J Mol Sci. 2019, 20, 2340.
Effects of a selective casein kinase 1δ and ε inhibitor on FcεRI expression and IgE-mediated immediate-type cutaneous reactions in dogs. Ohno H, Takahashi K, Yanuma N, Ogawa M, Hasegawa A, Sugita K, Kawano K, Sasaki K, Shirai J, Nagaoka K, Ohmori K. J Vet Med Sci. 2019 Dec 5;81(11):1680-1684.
Samir H, Kandiel MMM, El-Maaty AMA, Sediqyar M, Sasaki K, Watanabe G. Ovarian follicular changes and hemodynamics in Egyptian buffaloes under CIDR-PGF2α and Ovsynch-CIDR estrus synchronization treatments. J Reprod Dev. 2019 Oct 23;65(5):451-457
2018
Ogawa M, Osada H, Hasegawa A, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Kondo H, Ohmori K. Effect of interleukin-1β on occludin mRNA expression in the duodenal and colonic mucosa of dogs with inflammatory bowel disease. J Vet Intern Med. 2018 May;32(3):1019-1025
臼井達哉, 佐々木一昭. 2018. 肺がんオルガノイド・血管内皮細胞共培養システムを用いた細胞間相互作用メカニズムの解明. BIO Clinica. 34: 45-49.
Elbadawy M, Usui T, Yamawaki H, Sasaki K. Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. Int J Mol Sci. 2018 Oct 4;19(10). pii: E3031
Yabe R, Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T, Sato K. A stable association with PME-1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation. FEBS Open Bio. 2018 Aug 1;8(9):1486-1496.
Ogushi N, Sasaki K, Shimoda M. Effects of leucovorin (folinic acid) in the methotrexate-treated rat brain. J Vet Med Sci. 2018 May 18;80(5):760-765.
Elbadawy M, Usui T, Yamawaki H, Sasaki K. Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers (Basel). 2018 May 28;10(6). pii: E164
Usui T, Sakurai M, Umata K, Elbadawy M, Ohama T, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K, Kaneda M, Sasaki K. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture. Int J Mol Sci. 2018 Apr 6;19(4). pii: E1098.
臼井達哉, 佐々木一昭. 2018. 三次元マウス肺がんモデルの確立とがん・血管内皮連関機構の解明. メディカル・サイエンス・ダイジェスト 44: 189-192.
Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, UsuiT, Ohama T, Sato K. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. Mol Cancer Res. Accepted.
Usui T, Sakurai M, Umata K, Yamawaki H, Ohama T, Sato. Preparation of human primary colon tissue-derived organoid using air liquid interface culture. Curr Protoc Toxicol. Accepted. 2018
Hasegawa A, Watanabe M, Osada H, Ogawa M, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Ohmori K. Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains. Biochem Biophys Res Commun. 495(3):2184-2188, 2018
2017
Usui T, Sakurai M, Nishikawa S, Umata K, Nemoto Y, Haraguchi T, Itamoto K, Mizuno T, Noguchi S, Mori T, Iwai S, Nakagawa T, Yamawaki H, Ohama T, Sato K. Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells. Cancer Sci. 2017 Dec;108(12):2383-2392.
Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T, Sato K. The role of SET/I2PP2A in canine mammary tumors. Sci Rep. 7: 4279. 2017.
Kawasaki H, Saotome T, Usui T, Ohama T, Sato K. Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor. Oncol Rep. 37:3128-3136. 2017.
Usui T, Sakurai M, Kawasaki H, Ohama T, Yamawaki H, Sato K. Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis. Physiol Rep. 5:e13318.2017.
Nagasue R, Murata I, Sasaki K, Sakai R, Miyajima H, Shimoda M. Effectiveness of the liver micronucleus assay using juvenile mice. J Vet Med Sci.. 79(7):1310-1317. 2017
Osada H, Ogawa M, Hasegawa A, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Kondo H, Ohmori K. Expression of epithelial cell-derived cytokine genes in the duodenal and colonic mucosae of dogs with chronic enteropathy. J Vet Med Sci.. 79(2):393-397. 2017
Ogushi N, Sasaki K, Shimoda M. CAN a P-gp modulator assist in the control of methotrexate concentrations in the rat brain? -inhibitory effects of rhodamine 123, a specific substrate for P-gp, on methotrexate excretion from the rat brain and its optimal route of administration. J Vet Med Sci. 79(2):320-327. 2017
2016
Usui T, Sakurai M, Enjoji S, Kawasaki H, Umata K, Ohama T, Fujiwara N, Yabe R, Tsuji S, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment. Stem cells int. 7053872. 2016.
Tsuji S, Yabe R, Usui T, Mizuno T, Ohama T, Sato K. Anti-tumor effects of perphenazine on canine lymphoma. J Vet Med Sci. 78:1293-1298. 2016.
Kake S and *Usui T, Ohama T, Sato K. Death-associated protein kinase 3 controls tumor progression of A549 cells through ERK MAPK/c-Myc signaling. Oncol rep. 37:1100-1106. 2016.
Fujiwara N, Usui T, Ohama T, Sato K. Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). J Biol Chem. 291:10858-10866. 2016.
Watanabe M, Osada H, Shimizu S, Goto S, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Ohmori K. Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. Am J Vet Res. 77(9):969-75. 2016
Goto S, Shimizu S, Watanabe M, Osada H, Sasaki K, Shimoda M, Nagai M, Shirai J, Itoh H, Ohmori K. Influence of glucocorticoids on a time-of-day-dependent variation in intradermal reactivity to histamine in dogs. Vet J. 214:86-90. 2016
Sawaguchi A, Sasaki K, Miyanaga K, Nakayama M, Nagasue M, Shimoda M. Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle. J Vet Med Sci. 78(9):1481-1485. 2016
Elbadawy M, Ishihara Y, Aboubakr M, Sasaki K, Shimoda M. Oral absorption profiles of sulfonamides in Shiba goats: a comparison among sulfadimidine, sulfadiazine and sulfanilamide. J Vet Med Sci. 78(6):1025-9. 2016
2015
Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T, Sato K. Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation. PLoS One. 10:e0145226. 2015.
Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K. The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. J Vet Med Sci. 77:1451-1456. 2015.
Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, Yamawaki H. Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells. Acta Physiologica (Oxf) 213:472-480. 2015.
Sasaki K, Shimoda M. Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review. J Adv Res. 6(3):383-92. 2015
Elbadawy M, Sasaki K, Miyazaki Y, Aboubakr M, Khalil WF, Shimoda M. Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats. J Vet Med Sci. ;77(10):1331-4. 2015
E Ogushi N, Sasaki K, Shimoda M. Effect of cyclosporin on distribution of methotrexate into the brain of rats. J Vet Med Sci. ; 77(9):1171-3. 2015
Elbadawy M, Sakiyama T, Abohatab R, Sasaki K, Shimoda M. Oral pharmacokinetics of the acidic drugs, diclofenac and sulfamonomethoxine in male Shiba goats. J Vet Med Sci. ; 77(1):21-6. 2015
2014
Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T, Sato K. Characterization of SET/I2PP2A isoforms in dogs. J Vet Med Sci. 76:1235-1240. 2014.
Usui T, Sakatsume T, Nijima R, Otani K, Kazama K, Morita T, Kameshima S, Okada M, Yamawaki H. Death-associated protein kinase3 mediates vascular structural remodeling via stimulating smooth muscle cell proliferation and migration. Clin Sci (Lond). 127:539-548. 2014.
Usui T, Naruo A, Okada M, Hayabe Y, Yamawaki H. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells. Acta Physiologica (Oxf). 211:385-394. 2014.
Usui T, Morita T, Okada M, Yamawaki H. Histone deacetylase (HDAC) 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells. Hypertension. 63:397-403. 2014.
Usui T, Okada M, Yamawaki H. Zipper interacting protein kinase (ZIPK): function and signaling. Apoptosis. 19:387-391. 2014.
2013
臼井達哉, 岡田宗善, 原幸男, 山脇英之. 2013. 高血圧症の病態を制御する新たなカルモジュリン関連蛋白質の血管系における機能. 日本薬理学雑誌. 141: 85-89.